George F Koob Selected Research

CRF receptor type 1

1/2018	Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism.
3/2015	Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.
1/2015	Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats.
4/2009	Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.

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George F Koob Research Topics

Disease

45	Alcoholism (Alcohol Abuse) 01/2022 - 04/2002
39	Substance-Related Disorders (Drug Abuse) 11/2022 - 07/2002
18	Cocaine-Related Disorders (Cocaine Addiction) 01/2019 - 01/2002
16	Opioid-Related Disorders (Opiate Addiction) 01/2022 - 07/2002
8	Pain (Aches) 01/2021 - 07/2010
8	Hypersensitivity (Allergy) 01/2018 - 02/2008
7	Heroin Dependence (Heroin Abuse) 01/2019 - 07/2011
7	Tobacco Use Disorder (Nicotine Dependence) 01/2015 - 02/2004
5	Hyperalgesia 05/2021 - 07/2010
4	Body Weight (Weight, Body) 01/2019 - 01/2003
3	Chronic Pain 05/2021 - 01/2015
3	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2021 - 11/2008
3	Neuroinflammatory Diseases 01/2019 - 07/2014
3	Mental Disorders (Mental Disorder) 08/2018 - 01/2012
3	Seizures (Absence Seizure) 01/2007 - 02/2004
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022 - 02/2012
2	Wounds and Injuries (Trauma) 01/2021 - 02/2012
2	Parkinson Disease (Parkinson's Disease) 11/2020 - 07/2014
2	Inflammation (Inflammations) 11/2019 - 01/2019
2	Binge Drinking 01/2011 - 02/2008
2	Hyperphagia (Overeating) 11/2009 - 03/2006
2	Encephalitis (Encephalitis, Rasmussen) 01/2007 - 03/2006
2	Epilepsy (Aura) 03/2006 - 02/2004
2	Morphine Dependence 10/2004 - 02/2003
1	Anhedonia 01/2022
1	Ketosis 01/2021
1	Brain Injuries (Brain Injury) 01/2020
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2020
1	Ischemia 01/2020

Drug/Important Bio-Agent (IBA)

40	Pharmaceutical PreparationsIBA 11/2022 - 07/2002
20	Corticotropin-Releasing HormoneIBA 01/2022 - 10/2002
15	Ethanol (Ethyl Alcohol)IBA 01/2021 - 04/2002
14	Opioid Analgesics (Opioids)IBA 05/2021 - 08/2005
13	Heroin (Diamorphine)IBA 05/2021 - 12/2006
10	Cocaine (Cocaine HCl)IBA 01/2020 - 01/2002
8	Dynorphins (Dynorphin)IBA 05/2021 - 02/2004
8	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 02/2003
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2004
6	VaccinesIBA 05/2013 - 03/2011
5	Naloxone (Narcan)FDA LinkGeneric 01/2018 - 01/2005
5	Nicotine FDA Link 04/2015 - 07/2010
5	Opiate AlkaloidsIBA 12/2013 - 07/2002
4	Dopamine (Intropin)FDA LinkGeneric 11/2020 - 04/2002
4	CRF receptor type 1IBA 01/2018 - 04/2009
4	Naltrexone (ReVia)FDA LinkGeneric 08/2012 - 02/2008
4	Neuropeptide YIBA 06/2011 - 02/2003
4	Neurotransmitter Agents (Neurotransmitter)IBA 06/2011 - 01/2002
4	CannabinoidsIBA 04/2009 - 04/2002
4	Morphine (MS Contin)FDA LinkGeneric 11/2008 - 07/2002
3	Opioid Receptors (Opioid Receptor)IBA 01/2022 - 08/2012
3	LigandsIBA 05/2021 - 06/2010
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2006
3	Opioid Peptides (Opioid Peptide)IBA 01/2011 - 01/2003
3	Glutamic Acid (Glutamate)FDA Link 01/2011 - 02/2003
3	Acamprosate (Campral)FDA Link 01/2010 - 01/2005
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2022 - 01/2021
2	Ghrelin ReceptorsIBA 01/2022 - 01/2019
2	Mifepristone (RU 486)FDA Link 01/2022 - 08/2015
2	Acetates (Acetic Acid Esters)FDA Link 01/2021 - 01/2021
2	Aldehyde DehydrogenaseIBA 01/2021 - 12/2019
2	EnzymesIBA 12/2019 - 11/2006
2	Messenger RNA (mRNA)IBA 11/2019 - 01/2017
2	Biological ProductsIBA 01/2019 - 08/2018
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 04/2015 - 02/2011
2	Propranolol (Inderal)FDA LinkGeneric 03/2015 - 10/2010
2	kappa Opioid Receptors (kappa Opioid Receptor)IBA 10/2013 - 06/2010
2	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)IBA 04/2013 - 04/2011
2	Buprenorphine (Subutex)FDA LinkGeneric 08/2012 - 01/2005
2	Narcotic Antagonists (Opioid Antagonists)IBA 08/2012 - 01/2007
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/2010 - 07/2008
2	EndocannabinoidsIBA 04/2009 - 04/2002
2	Methamphetamine (Desoxyn)FDA LinkGeneric 07/2007 - 03/2006
2	UrocortinsIBA 05/2007 - 08/2002
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2007 - 03/2006
2	Serotonin (5 Hydroxytryptamine)IBA 02/2003 - 07/2002
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	AcyltransferasesIBA 01/2022
1	GhrelinIBA 01/2022
1	Analgesics (Analgesic Drugs)IBA 05/2021
1	norbinaltorphimineIBA 05/2021
1	17- cyclopropylmethyl- 6,7- didehydro- 4,5- epoxy- 5'- guanidinyl- 3,14- dihydroxyindolo(2',3'- 6,7)morphinanIBA 05/2021
1	acetoacetic acid (acetoacetate)IBA 01/2021
1	KetonesIBA 01/2021
1	Ketone BodiesIBA 01/2021
1	PlacebosIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	EstersIBA 01/2021
1	AcetoneIBA 01/2021
1	Interleukin-17 (Interleukin 17)IBA 01/2020
1	Interleukin-17 ReceptorsIBA 01/2020
1	AcetaldehydeIBA 12/2019
1	ChemokinesIBA 11/2019
1	CytokinesIBA 11/2019
1	Monoclonal AntibodiesIBA 11/2019

Therapy/Procedure

19	Self Administration (Administration, Self) 01/2019 - 10/2002
9	Therapeutics 01/2021 - 11/2008
6	Drug Therapy (Chemotherapy) 01/2018 - 08/2003
2	Analgesia 05/2021 - 11/2012
2	Ketogenic Diet 01/2021 - 01/2021